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  1. Frank Larkin, Editor in Chief
  1. Cornea and External Diseases Service, Moorfields Eye Hospital, London, UK
  1. Correspondence to Frank Larkin, Cornea and External Diseases Service, Moorfields Eye Hospital, London, UK; f.larkin{at}

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Descemet’s membrane endothelial keratoplasty is the predominant keratoplasty procedure in Germany since 2016: a report of the DOG-section cornea and its keratoplasty registry (see page 646)

This study summarises absolute numbers, types of and indications for corneal transplants in Germany from 2011 to 2021. It compares these trends with equivalent international data.

Visual function after ultrathin Descemet’s stripping automated endothelial keratoplasty or Descemet’s membrane endothelial keratoplasty combined with cataract surgery: a randomised controlled clinical trial (see page 654)

Descemet’s membrane endothelial keratoplasty (DMEK) resulted in better visual acuity and higher endothelial cell density than ultrathin Descemet’s stripping automated endothelial keratoplasty (DSAEK) 12 months after surgery, whereas contrast sensitivity was comparable.

Repeat corneal collagen cross linking after failure of primary cross-linking in Keratoconus (see page 662)

Repeat corneal collagen cross-linking is reported to be safe and effective for stabilisation of keratoconus that has progressed following primary collagen cross-linking. This is one of the first studies to address failed cross-linking and management of these keratoconus patients.

Detecting the corneal neovascularisation area using artificial intelligence (see page 667)

This report describes use of an automated tool using artificial intelligence to calculate the total corneal area and corneal neovascularisation (CoNV) area more precisely and objectively from slit lamp images in patients with corneal vascularisation.

Repeatability and reproducibility of a new fully automatic measurement optical low coherence reflectometry biometer and agreement with swept-source optical coherence tomography-based biometer (see page 673)

This study demonstrated that the new Suoer SW-9000 μm Plus biometer had excellent repeatability and reproducibility in measuring ocular parameters, and it is interchangeable with the SS-OCT-based IOLMaster 700.

Intravitreal bevacizumab improves trabeculectomy survival at 12 months: the bevacizumab in trabeculectomy study—a randomised clinical trial (see page 679)

In this double-blind randomised placebo-controlled trial, higher rates of 12 month success following trabeculectomy with mitomycin-C were observed with a single intraoperative dose of intravitreal bevacizumab.

Ab interno canaloplasty versus gonioscopy-assisted transluminal trabeculotomy in open-angle glaucoma: a randomised controlled trial (see page 687)

Gonioscopy-assisted Transluminal Trabeculotomy (GATT) provided an additional intraocular pressure effect compared with Ab Interno Canaloplasty (ABiC) in OAG patients. Mild, transient postoperative complications were observed and both procedures had acceptable safety profiles.

Differentiating glaucoma from chiasmal compression using optical coherence tomography: the macular naso-temporal ratio (see page 695)

The macular naso-temporal ratio, an optical coherence tomography-based metric characterising the spatial distribution of ganglion cell-inner plexiform layer thinning, is a novel and accurate index for discriminating chiasmal lesions from primary open angle glaucoma.

Automated expert-level scleral spur detection and quantitative biometric analysis on the Anterion anterior segment OCT system (see page 702)

Deep learning algorithms on the ANTERION OCT system (Heidelberg Engineering) approximate expert-level detection of the scleral spur and measurement of anterior segment biometric parameters in a real-world clinical cohort, improving accessibility of these data.

Impact of gender on clinical features and outcomes of ocular toxoplasmosis (see page 710)

We explored the effects of gender on ocular toxoplasmosis. Although similar by gender, ocular toxoplasmosis was more likely to be recurrent when active, involve the posterior pole, and cause multiple retinal lesions in women.

Five-year results of atropine 0.01% efficacy in the myopia control in a European population (see page 715)

This article describes the result of the first study in Spain with a 5 year follow-up of subjects using low concentration atropine as myopia control treatment in a Caucasian paediatric population. Comparisons are made with the number of trials addressing the effectiveness of atropine drops in East Asia.

Myopic maculopathy among Chinese children with high myopia and its association with choroidal and retinal changes: the scale-Hm study (see page 720)

Maculopathy is highly prevalent in highly myopic Chinese children. Nasal macular choroidal thickness may serve as an indicator to assess myopic maculopathy.

Survival of patients with recurrent uveal melanoma after treatment with radiation therapy (see page 729)

Local recurrence after radiation therapy for uveal melanoma was associated with a greater than 3.5-fold increase in the risk of melanoma-related mortality after accounting for baseline tumour size.

One-field, two-field and five-field handheld retinal imaging compared with standard seven-field early treatment diabetic retinopathy study photography for diabetic retinopathy screening (see page 735)

Acquisition of additional peripheral fields when using handheld retinal imaging devices decreased the ungradable rate and increased identification of referable diabetic retinopathy. This suggests a substantial benefit of using peripheral fields in handheld imaging retinopathy screening programmes.

Autonomous screening for laser photocoagulation in fundus images using deep learning (see page 742)

This study report the development and validation of an AI model for the detection of laser photocoagulation artefacts in fundus images. The use of this model improves the performance of other AI fundus models and improved on the results and conditions of previous similar studies.

Effect of socioeconomic deprivation as determined by the English deprivation deciles on the progression of diabetic retinopathy and maculopathy: a multivariate case-control analysis of 88 910 patients attending a south-east London diabetic eye screening service (see page 747)

Index of multiple deprivation (IMD) subdomains uncover associations between specific aspects of deprivation and referable diabetic retinopathy and maculopathy, which may be otherwise missed when using the aggregate IMD as a measure of relative deprivation.

Pachyvitelliform maculopathy: an optical coherence tomography analysis of a novel entity (see page 753)

This report describes a novel entity in the pachychoroid disease spectrum: Pachychoroid vitelliform maculopathy.

Progression, reliability, predicting parameters, and sample-size calculations for quantitative fundus autofluorescence measures in ABCA4-related retinopathy (see page 760)

Quantitative autofluorescence imaging might be suitable for effectively quantifying disease progression and therapeutic effects. Adapted trial design based on baseline characteristics and individual genotypes provides benefits concerning the required sample size and study duration.

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  • Contributors I am the sole author.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.