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  1. Frank Larkin, Editor in Chief
  1. Cornea and External Diseases Service, Moorfields Eye Hospital, London, UK
  1. Correspondence to Professor Frank Larkin, Cornea and External Disease Department, Moorfields Eye Hospital NHS Foundation Trust, London, UK; f.larkin{at}

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Cataract surgery workload estimates in Theni district, India (see page 915)

In Theni district, India, based on current utilisation of eye care services and prevalence of vision impairment, a 5-year goal of eliminating vision impairment would require that the annual cataract surgical workload increase by 11.5%. Studies of this kind may have considerable value in planning service delivery in other locations.

Accuracy of using the axial length of the fellow eye for IOL calculation in retinal detachment eyes undergoing silicone oil removal (see page 921)

Using the axial length of the fellow eye in eyes with retinal detachment results in a clinically significant reduction of predictability of the postoperative refraction. Therefore, rather than combined phako-vitrectomy, a two-step procedure should be favoured, if possible, in which vitrectomy is undertaken first and measurements for IOL selection performed after reattachment of the retina.

Deep-learning-based prediction of glaucoma conversion in normotensive glaucoma suspects (see page 927)

Deep-learning models trained with both fundus images and 15 features from the clinical information showed excellent diagnostic abilities in predicting glaucoma progression in glaucoma suspect patients with normal intraocular pressure.

Evaluating the outcome of screening for glaucoma using colour fundus photography-based referral criteria in a teleophthalmology screening program for diabetic retinopathy (see page 933)

Opportunistic detection of glaucoma on fundus photographs in national diabetic retinopathy screening found 9% of patients had glaucoma. Referring patients with vertical-cup-to-disc ratio of 0.65 showed moderate sensitivity but low specificity and positive predictive value.

Investigating the determinants of iridolenticular contact area: a novel parameter for angle closure (see page 940)

Iridolenticular contact area is a novel biometric predictor of angle closure and may reflect unique anatomical changes associated with angle closure risk independent of other lens-related and iris-related parameters.

Ocular blood flow biomarkers may predict long-term structural and functional glaucoma progression (see page 946)

Baseline blood flow biomarkers may be long-term predictors of structural and functional glaucoma progression, indicating the potential value of including vascular assessment in glaucoma.

Effectiveness of difluprednate in addition to systemic therapy for the treatment of anterior scleritis (see page 951)

In patients with anterior scleritis treated with systemic therapy, the addition of difluprednate resulted in clinical resolution in almost 80% of the treated eyes. Difluprednate can be used as an option for the treatment of active anterior scleritis in patients using systemic therapy.

Efficacy and safety of hyperbaric oxygen therapy monitored by fluorescein angiography in patients with retinal artery occlusion (see page 956)

Hyperbaric oxygen therapy, administered twice daily until revascularisation of the central retinal artery monitored by fluorescein angiography, was safe and allowed visual acuity improvement (defined as a gain ≥0.3 logMAR) in 48.4% of patients presenting with retinal artery occlusion.

Comparative study of widefield swept source optical coherence tomography angiography in eyes with concomitant age-related macular degeneration and diabetic retinopathy (see page 963)

Compared to eyes affected by age-related macular degeneration alone, eyes with concomitant age-related macular degeneration and diabetic retinopathy have reduced retinal microvasculature when evaluated with widefield swept-source optical coherence tomography.

Approved artificial intelligence (AI)-based fluid monitoring to identify morphological and functional treatment outcomes in neovascular age-related macular degeneration (nAMD) in real-world routine practice (see page 971)

Deep-learning-based image segmentation methods provide high precision in retinal fluid quantification. This study reports that a regulator-approved AI-based fluid monitoring algorithm can predict anti-vascular endothelial growth factor (VEGF) treatment requirements and late-stage outcomes in nAMD.

Variability of scan quality and perfusion density in longitudinal optical coherence tomography angiography imaging (see page 978)

The authors present evidence that optical coherence tomography angiography imaging is affected by increasing experience of either the operator or subject, or a combination of each, when serial imaging is performed.

Deep learning detection of diabetic retinopathy in Scotland’s diabetic eye screening programme (see page 984)

A deep-learning-based grader for diabetic retinopathy, trained against screening programme grades, is reported to have greater efficacy than iGradingM, the support vector machine-based autograder which has been safely reducing manual grading effort in the Scottish Diabetic Eye Service since 2011.

Network pharmacology and biochemical experiments reveal the antiapoptotic mechanism of huperzine for treating diabetic retinopathy (see page 989)

Huperzine A is a natural plant-based drug that has been used in neurodegenerative disorders. This drug was found to have protective effects in a rat diabetic retinopathy model. Network pharmacology analysis and biochemical experiments had indicated that it could act on heat-shock protein (HSP)-27 and play a neuroprotective role through apoptosis-related pathways.

Automated classification of multiple ophthalmic diseases using ultrasound images by deep learning (see page 999)

A deep-learning-based model was developed and evaluated for the automated classification of multiple ophthalmic diseases using 9723 B-mode ultrasound images from multiple devices. Clinically confirmed diagnosis categories included normal, retinal detachment, vitreous haemorrhage, intraocular tumour and posterior scleral staphyloma. The proposed model achieved an accuracy of 87.8%.

Ki67 is a better marker than PRAME in risk stratification of BAP1-positive and BAP1-loss uveal melanomas (see page 1005)

In a study of 164 enucleated uveal melanomas, low Ki67 proliferation index correlated with better survival in BAP1-loss and BAP1-positive tumours. A panel of Ki67 and BAP1 may be a helpful risk stratification method for metastasis and melanoma-related death.

Subset of retinoblastoma tumours are associated with BRCA1/2 mutations (see page 1011)

Some retinoblastoma patients carry BRCA1/2 family germline variants, which may have a role in mediating the pathogenicity of retinoblastoma, with or without RB1 mutations.

Axial length elongation profiles from 3 to 6 year olds in an Asian paediatric population: the Growing Up in Singapore Towards Health Outcomes Birth Cohort Study (GUSTO) (see page 1018)

This preschool study reveals average axial length elongation of 0.8 mm between ages 3 and 6 years, with myopes showing the most change. Differences in AL elongation among myopes, emmetropes and hypermetropes can be useful in identifying myopia development.

Normative value of hyperopia reserve and myopic shift in 3-to-16-year-old Chinese children and adolescents (see page 1024)

Age-specific normative values of hyperopia reserve and yearly myopic shift of 3-to-16-year-old Chinese children and adolescents are provided in this 1-year follow-up study.

Development of a joint set of database parameters for the EU-ROP and fight childhood blindness! ROP registries (see page 1030)

The authors present a set of parameters to be used in registries, studies and by clinicians in routine clinical practice. These form the basis of the EU-ROP and the Fight Childhood Blindness! ROP Registries.

Measurement of visual function in infantile nystagmus: a systematic review (see page 1038)

The suitability of visual acuity to measure changes in visual function in infantile nystagmus has long been debated. No appropriate alternative yet exists. Several factors have been shown to affect visual performance in infantile nystagmus.

The efficacy of augmented-dosed surgery versus botulinum toxin A injection for acute acquired concomitant esotropia: a 2-year follow-up (see page 1044)

Although both augmented-dosed surgery and botulinum toxin type A injection are effective treatment options for acute acquired concomitant esotropia, the former tends to result in more stable outcomes.

Impact of refresher training on outcomes of trachomatous trichiasis surgery (see page 1049)

In this prospective cohort study, 5-day refresher training using surgical simulation plus supportive live surgery supervision for established trachomatous trichiasis (TT) surgeons was associated with a statistically significant 12.4% (p=0.03) lower postoperative TT 1-year incidence.

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  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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