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Synapse formation in retinoblastoma tumours.
  1. D H Dickson,
  2. M S Ramsey and
  3. J G Tonus


    Developing photoreceptor-like cells in retinoblastoma tumour fleurettes were found to contain apical tight junctions, mitochondrial-filled inner segment regions with cilia, and basally located synaptic ribbons and vesicles. Synaptic contract appeared to be established with adjacent neuronal-like elements. We suggest that photoreceptor differentiation in retinoblastoma tumours follows a sequence similar to normal human photoreceptor embryogenesis.

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