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Combined vitamin A and E therapy prevents retinal electrophysiological deterioration in abetalipoproteinaemia.
  1. S Bishara,
  2. S Merin,
  3. M Cooper,
  4. E Azizi,
  5. G Delpre and
  6. R J Deckelbaum


    Eight patients with abetalipoproteinaemia had the typical ocular, systemic, and laboratory findings of this disease. Combined therapy with vitamins A and E was administered, starting as early as the first day of life and as late as 26 years of age. The patients were followed up for 2-6 years. Electroretinography was undertaken in all cases and electrooculography in some. After initiation of vitamin A and E therapy no progression of disturbed visual function could be detected in any patient. These objective tests of retinal function demonstrated that the combined vitamin A and E therapy may be useful in arresting retinal deterioration in abetalipoproteinaemia.

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