The hypotensive effect of a combination of guanethidine 1% with adrenaline 1% was compared with adrenaline 1% alone on the eyes of 20 patients with ocular hypertension in a randomised double-blind cross-over trial. The patients received 8 weeks of treatment with each preparation. A significant increase in the hypotensive effect was found by adding guanethidine 1% to adrenaline 1%. This hypotensive effect was maintained over the 8-week period of the trial.
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