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Preliminary results of proton beam irradiation of macular and paramacular melanomas.
  1. E S Gragoudas,
  2. M Goitein,
  3. J Seddon,
  4. L Verhey,
  5. J Munzenrider,
  6. M Urie,
  7. H D Suit,
  8. P Blitzer,
  9. K N Johnson and
  10. A Koehler


    Proton beam irradiation has been used for the treatment of 60 eyes with choroidal melanomas located 3 mm or less from the fovea. The average follow-up period was 18 months. 86% of the treated lesions showed regression at the time of this analysis, and the 14% that did not were followed up for less than a year. Visual acuity remained the same in 47% of the treated eyes, improved in 20%, and deteriorated in 33%. 58% of the treated eyes had visual acuity of 20/100 or better at the last follow-up examination. Radiation vasculopathy with macular oedema was the most common complication, and it was observed in 22% of the treated eyes. These preliminary observations suggest that proton beam irradiation may be a reasonable alternative to enucleation even for this group of choroidal melanomas, which is considered unfavourable in respect of the preservation of visual function.

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