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Ocular and cardiovascular response to topical carteolol 2% and timolol 0.5% in healthy volunteers.
  1. D. J. Brazier and
  2. S. E. Smith
  1. Department of Clinical Pharmacology, St Thomas's Hospital Medical School (UMDS), London.


    Ocular and cardiovascular effects of carteolol 2%, timolol 0.5%, and dummy eyedrops have been measured in a single dose double-blind crossover study in six healthy volunteers. Both drugs lowered intraocular pressure and reduced exercise-induced tachycardia. Neither produced a significant change in resting heart rate or blood pressure. The two agents appear comparable as regards ocular hypotensive and cardiovascular effects.

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