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Dopamine-2 receptor blockade does not affect the ocular hypotensive action of timolol.
  1. Q A Mekki and
  2. P Turner
  1. Department of Clinical Pharmacology, St Bartholomew's Hospital Medical College, London.


    We have shown that metoclopramide, a dopamine-2 antagonist, failed to antagonise the ocular hypotensive action of timolol. The practical implication of combining dopamine agonists with beta-adrenoceptor antagonists in the treatment of glaucoma is discussed.

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