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Bromovinyldeoxyuridine and interferon treatment in ulcerative herpetic keratitis: a double masked study.
  1. O P van Bijsterveld,
  2. P J Meurs,
  3. E de Clercq and
  4. P C Maudgal
  1. Royal Dutch Eye Clinic, Utrecht, The Netherlands.


    Bromovinyldeoxyuridine is a potent and safe antiherpes compound that in combination with a placebo treatment promoted the partial and complete healing of herpetic epithelial disease in 22 patients in average times of 4-6 days and 8.5 days respectively. However, when BVDU was combined with 1.5 X 10(6) IU of recombinant a 2C interferon, partial and complete healing times for keratitis in 19 patients were reduced to 2-6 days and 4-6 days respectively. No toxic effects of the medications were observed in any patient.

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