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Improved iodine-125 plaque design in the treatment of choroidal malignant melanoma.
  1. J C Hill,
  2. R Sealy,
  3. D Shackleton,
  4. C Stannard,
  5. J Korrubel,
  6. E Hering and
  7. C Loxton
  1. Department of Ophthalmology, Groote Schuur Hospital.


    The use and development of iodine-125 plaque therapy for choroidal malignant melanoma are described. Since 1975 experience has led to changes in plaque design and insertion techniques. Twenty-one patients were irradiated with local episcleral iodine-125 plaques. Three patients required a second plaque for tumour recurrence. Four eyes were enucleated because of continued tumour growth and a further eye was removed because of glaucoma secondary to radiation retinopathy. Two patients (9.5%) died of metastases. The remaining 19 patients are alive and clinically clear of metastases, with a mean follow up time of 73.1 months (range 43-142 months).

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