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Late onset Leber's optic neuropathy: a case confused with ischaemic optic neuropathy.
  1. F X Borruat,
  2. W T Green,
  3. E M Graham,
  4. M G Sweeney,
  5. J A Morgan-Hughes and
  6. M D Sanders
  1. National Hospital for Neurology and Neurosurgery, Neuro-Ophthamology Unit, Queen Square, London.


    A case is reported of a 63-year-old man with progressive central visual loss in one eye followed 11 months later by involvement of the fellow eye. A diagnosis of chronic ischaemic optic neuropathy was considered. However, despite a negative family history, the absence of electrocardiographic abnormalities, and minimal fundus changes a diagnosis of Leber's optic neuropathy was made on the basis of magnetic resonance imaging findings and the mitochondrial DNA mutation at base pair 11778.

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