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DNA index and S phase fraction in uveal malignant melanomas.
  1. W G Hodge,
  2. A J Duclos,
  3. G Rocha,
  4. E Antecka,
  5. M G Baines,
  6. C Corriveau,
  7. S Brownstein and
  8. J Deschenes
  1. Department of Ophthalmology, McGill University, Montreal, Quebec, Canada.


    AIMS--To predict 5 year survival in patients with uveal malignant melanomas DNA indices were studied. METHODS--Using 45 paraffin embedded uveal malignant melanomas, the DNA index and S phase fraction of each tumour were the predictor variables recorded. RESULTS--Using the Cox proportional hazards model, aneuploid tumours and tumours which had an S phase fraction greater than 4% were significant predictors of early death. In order to demonstrate a biological gradient between a larger DNA index and shorter survival time, linear regression and transformed linear regression models were used. However, no such gradient could be demonstrated. CONCLUSION--Although this study shows promise for the use of DNA studies in the prognosis of uveal malignant melanoma, the exact role of these techniques remains to be determined.

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