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Regression of conjunctival Kaposi’s sarcoma under chemotherapy with bleomycin
  1. HEINRICH HEIMANN,
  2. KLAUS M KREUSEL,
  3. MICHAEL H FOERSTER
  1. Department of Ophthalmology
  2. Department of Dermatology
  3. University Hospital Benjamin Franklin, Free University of Berlin
  4. Berlin, Germany
  1. RALF HUSAK,
  2. CONSTANTIN E ORFANOS
  1. Department of Ophthalmology
  2. Department of Dermatology
  3. University Hospital Benjamin Franklin, Free University of Berlin
  4. Berlin, Germany
  1. Dr H Heimann, Department of Ophthalmology, University Hospital Benjamin Franklin, Free University of Berlin, Hindenburgdamm 30, D-12200 Berlin, Germany.

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Editor,—Kaposi’s sarcoma (KS) is the most common neoplasm in patients with the acquired immunodeficiency syndrome (AIDS). In Europe, approximately 29% of patients with AIDS are affected; the tumour occurs much more frequently among HIV infected homosexual men compared with patients who contracted HIV through different routes of infection.12 Increasing evidence points to the role of the human herpesvirus 8 (HHV8) as a causative infectious agent for KS in immunosuppressed patients. It has not as yet been clarified, however, if HHV8 is required for the development of KS or if the virus preferentially infects and reduplicates within KS.2

Disseminated KS is currently treated with single or multiple agent chemotherapy, immunotherapy, and/or radiation therapy. For limited local disease cryotherapy, surgical excision, or local chemotherapy can be employed.3 We present a case of regression of conjunctival KS under systemic chemotherapy with bleomycin.

CASE REPORT

A 36-year-old homosexual, clinically asymptomatic male was proved to be HIV positive in June 1994. Within 16 months the patient rapidly developed AIDS (CDC 3) showing severe psoriasis, oral candidiasis, and disseminated mucocutaneous KS. The development of clinical symptoms was …

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