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Understanding the natural history of a disease is essential to assess effective treatment and allocate resources. In a recent commentary in the BJO Hitchings1 decried the absence of a natural history of glaucoma and thus a control group against which to measure treatment. Fortunately, other medical problems, such as retinopathy of prematurity (ROP), have been subject to study before it became unethical to withhold treatment.23 Possession of this information, however, may pose more questions than answers.
The paper by Darlow et …