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Effectiveness of occlusion therapy in ametropic amblyopia: a pilot study
  1. Merrick J Moseleya,
  2. Alistair R Fieldera,
  3. Mary Irwinb,
  4. Helen S Jonesb,
  5. Rosemary J Auldc
  1. aAcademic Unit of Ophthalmology, Imperial College of Science, Technology and Medicine, London, bAcademic Unit of Ophthalmology, The University of Birmingham, Birmingham, cDepartment of Orthoptics, The Birmingham and Midland Eye Centre, Birmingham
  1. Dr M J Moseley, Academic Unit of Ophthalmology, The Western Eye Hospital, Marylebone Road, London NW1 5YE.


AIMS/BACKGROUND To examine the relative contributions of non-specific (for example, spectacle correction) and specific (that is, occlusion therapy) treatment effects on children with ametropic amblyopia. To assess the importance and practicality of objectively confirming the prescribed occlusion dose.

METHODS Subjects were entered into a two phase trial. In the first (‘pretreatment’) subjects were provided with spectacle correction and underwent repeat visual acuity (VA) and contrast sensitivity (CS) testing until acuity in their amblyopic eye had stabilised. Subjects then progressed to the second phase (‘treatment’) in which they underwent direct, unilateral occlusion for 1 hour per day for 4 weeks. Patching was objectively monitored using an occlusion dose monitor.

RESULTS Eight subjects completed the trial, all but one of whom achieved >80% concordance with the occlusion regimen. Within the pretreatment phase, mean amblyopic eye VA improved by 0.19 log units (p=0.008) while mean CS gained 0.09 log units (p=0.01). An identical improvement in mean VA was recorded in the fellow eyes (p=0.03) while mean CS gained 0.11 log units (p=0.02). Within the treatment phase, mean VA further improved (0.12 log units, p=0.009) although this gain had halved by the end of treatment and was no longer statistically significant (p=0.09).

CONCLUSIONS Visual performance improved significantly during pretreatment whereas further gains seen during occlusion were not sustained. Evaluation of occlusion regimens must take into consideration the potentially confounding influence of ‘pretreatment effects’ and the necessity to confirm objectively the occlusion dose a child receives.

  • amblyopia
  • occlusion therapy
  • perceptual learning
  • treatment effectiveness

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