You are here

Article Text

Article menu
Letter to the Editor
Elevation of serum IGF-1 precedes proliferative diabetic retinopathy in Mauriac’s syndrome
  1. E CHANTELAU,
  2. H EGGERT,
  3. T SEPPEL,
  4. E SCHÖNAU
  1. Department of Internal Medicine,
  2. Heinrich Heine University of Dusseldorf, Germany
  3. Department of Ophthalmology,
  4. Heinrich Heine University of Dusseldorf, Germany
  1. C ALTHAUS
  1. Department of Internal Medicine,
  2. Heinrich Heine University of Dusseldorf, Germany
  3. Department of Ophthalmology,
  4. Heinrich Heine University of Dusseldorf, Germany
  1. Ernst Chantelau, Diabetes-ambulanz MNR-Klinik, Heinrich-Heine University, PO Box 10 10 07, D-40001 Dusseldorf, Germany.

https://doi.org/10.1136/bjo.81.2.168b

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Editor,—Mauriac’s syndrome is a rare condition of insulin dependent diabetic children with long standing poor glycaemic control, growth retardation, and liver enlargement in whom improvement of diabetes control accelerates diabetic retinopathy.1 The cause of this paradoxical progression of diabetic retinopathy is unknown.

    CASE REPORT

    A 21-year-old man, diabetic since the age of 2, was first admitted to our hospital because of short stature and delayed sexual maturation. He presented with all signs of Mauriac’s syndrome: height 155 cm (below third percentile), body weight 41 kg, prepubertal sexual development (pubic hair Tanner stage 3, genital stage 2), liver enlargement, and subnormal serum concentration of insulin-like growth factor 1(IGF-1) of 162 ng/ml. His diabetes had been poorly controlled ever since, the actual HbA1c (normal < 5.6%, high performance liquid chromatography) being …

    View Full Text