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Letter to the Editor
Intraepithelial sebaceous neoplasia invading the lacrimal gland
  1. CORNELIA M MOOY
  1. Department of Pathology and Ophthalmology, Erasmus University, Room Ee 993, PO Box 1738, 3000 DR Rotterdam, Netherlands

    https://doi.org/10.1136/bjo.81.7.608f

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      Editor,—Intraepithelial sebaceous neoplasia of the ocular surface without an underlying invasive carcinoma is considered to be an incipient carcinoma. These lesions can remain in situ for prolonged periods without undergoing transformation to an invasive carcinoma.1 The diagnosis of intraepithelial sebaceous neoplasia is established by map biopsies, determining the extent of intraepithelial spread, excluding an occult invasive carcinoma. This is a report of a case with extensive intraepithelial sebaceous neoplasia, with invasive growth in the lacrimal gland.

      CASE REPORT

      A 77-year-old woman presented with a long term history of a chronic irritated right eye. On clinical examination the tarsal and bulbar conjunctival surface was irregular with vascular ingrowth. Full thickness biopsies from the upper and lower eyelid revealed an intraepithelial sebaceous carcinoma of the Bowenoid type. Clinically, the major part of the conjunctiva was affected and it was decided to perform …

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