Article Text

Download PDFPDF
Helicoidal peripapillary chorioretinal degeneration: electrophysiology and psychophysics in 17 patients
  1. Thor Eysteinssonb,
  2. Fridbert Jónassona,
  3. Vésteinn Jónssona,
  4. Alan C Birdc
  1. aDepartment of Ophthalmology, University of Iceland, Reykjavik, Iceland, bDepartment of Physiology, University of Iceland, Reykjavik, Iceland, cMoorfields Eye Hospital, University of London, City Road, London
  1. Thor Eysteinsson, Department of Physiology, University of Iceland, Vatnsmyrarvegi 16, 101 Reykjavik, Iceland.

Abstract

AIMS To characterise retinal function using electrophysiological and psychophysical tests in 17 patients with helicoidal peripapillary chorioretinal degeneration.

METHODS The electroretinogram (ERG) was recorded using gold foil corneal electrodes. The electro-oculogram (EOG) was recorded using a standard protocol. Dark adaptometry was recorded with an SST-1 dark adaptometer and colour vision assessed with Ishihara plates and Farnsworth D-15.

RESULTS All subjects had a recordable ERG. The amplitudes and implicit times of the a- and b-waves were within normal limits at all luminances in five subjects (age 21–70 years, mean 40 years). The ERG of six (age 26–55 years, mean 40.7 years) had subnormal amplitudes at all luminances, but normal implicit times, and six (age 38–81 years, mean 60.7 years) had abnormal ERGs with marked reduction of a- and b-waves, and delayed implicit times of the b-wave. The implicit times of the a-wave were normal in all subjects. A reduction in the b/a wave ratios was not found, nor was there selective loss of scotopic, mixed rod/cone, or cone responses. The light/dark ratio of the EOG was subnormal (150–185%) or abnormal (below 150%) in all but three subjects. Two patients with normal EOG showed normal ERGs in both eyes, but one had subnormal ERGs in both eyes. The scotopic sensitivity was normal in all subjects and dark adaptation showed a normal time course. Colour vision was normal in all patients.

CONCLUSION The results suggest that in most cases the function of the retinal pigment epithelium is affected by this disease before any changes in the function of the sensory retina are detectable by our methods, and that retinal dysfunction is focal rather than diffuse.

  • chorioretinal degeneration
  • electroretinogram
  • dark adaptation
  • colour vision

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Footnotes