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  • Expression of transforming growth factor β superfamily and their receptors in the corneal stromal wound healing process after excimer laser keratectomy

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Letter to the Editor
Expression of transforming growth factor β superfamily and their receptors in the corneal stromal wound healing process after excimer laser keratectomy
  1. YUICHI KAJI
  1. Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
  2. Second Department of Ophthalmology, University of Toho School of Medicine, Tokyo, Japan
  3. Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
  4. Department of Ophthalmology, Unversity of California School of Medicine, San Fransisco, USA
  5. Santen Pharmaceutical Co, Ltd, Nara Reserch and Developmental Center, Nara, Japan
  6. Department of Biochemistry, the Cancer Institute, Tokyo, Japan
  7. Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
  1. TOMONAO MITA
  1. Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
  2. Second Department of Ophthalmology, University of Toho School of Medicine, Tokyo, Japan
  3. Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
  4. Department of Ophthalmology, Unversity of California School of Medicine, San Fransisco, USA
  5. Santen Pharmaceutical Co, Ltd, Nara Reserch and Developmental Center, Nara, Japan
  6. Department of Biochemistry, the Cancer Institute, Tokyo, Japan
  7. Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
  1. HIROTO OBATA,
  2. TADAHIKO TSURU
  1. Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
  2. Second Department of Ophthalmology, University of Toho School of Medicine, Tokyo, Japan
  3. Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
  4. Department of Ophthalmology, Unversity of California School of Medicine, San Fransisco, USA
  5. Santen Pharmaceutical Co, Ltd, Nara Reserch and Developmental Center, Nara, Japan
  6. Department of Biochemistry, the Cancer Institute, Tokyo, Japan
  7. Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
  1. KOUICHI SOYA
  1. Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
  2. Second Department of Ophthalmology, University of Toho School of Medicine, Tokyo, Japan
  3. Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
  4. Department of Ophthalmology, Unversity of California School of Medicine, San Fransisco, USA
  5. Santen Pharmaceutical Co, Ltd, Nara Reserch and Developmental Center, Nara, Japan
  6. Department of Biochemistry, the Cancer Institute, Tokyo, Japan
  7. Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
  1. EIICHI SHIRASAWA,
  2. HIROYUKI SAKAI
  1. Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
  2. Second Department of Ophthalmology, University of Toho School of Medicine, Tokyo, Japan
  3. Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
  4. Department of Ophthalmology, Unversity of California School of Medicine, San Fransisco, USA
  5. Santen Pharmaceutical Co, Ltd, Nara Reserch and Developmental Center, Nara, Japan
  6. Department of Biochemistry, the Cancer Institute, Tokyo, Japan
  7. Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
  1. AKI HANYU,
  2. MITSUYASU KATO
  1. Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
  2. Second Department of Ophthalmology, University of Toho School of Medicine, Tokyo, Japan
  3. Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
  4. Department of Ophthalmology, Unversity of California School of Medicine, San Fransisco, USA
  5. Santen Pharmaceutical Co, Ltd, Nara Reserch and Developmental Center, Nara, Japan
  6. Department of Biochemistry, the Cancer Institute, Tokyo, Japan
  7. Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
  1. HIDETOSHI YAMASHITA
  1. Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
  2. Second Department of Ophthalmology, University of Toho School of Medicine, Tokyo, Japan
  3. Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
  4. Department of Ophthalmology, Unversity of California School of Medicine, San Fransisco, USA
  5. Santen Pharmaceutical Co, Ltd, Nara Reserch and Developmental Center, Nara, Japan
  6. Department of Biochemistry, the Cancer Institute, Tokyo, Japan
  7. Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
  1. Yuichi Kaji, MD, Department of Ophthalmology, University of Tokyo School of Medicine, Hongou 7-3-1, Bunkyo-ku, Tokyo, 113-8655 Japan.

https://doi.org/10.1136/bjo.82.4.456g

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    Editor,—Corneal stromal clouding (corneal haze) develops after excimer laser keratectomy. During the corneal wound healing process after excimer laser keratectomy, abnormal subepithelial fibrous tissue is formed just under the abraded area, where keratocytes proliferate and extracellular matrix (ECM) components, including collagens (type III, IV, and VII), fibronectin, laminin, and tenascin, are deposited.1-3 This abnormal ECM deposition is thought to correspond to the corneal haze.

    The transforming growth factor β (TGF-β) superfamily contains many multifunctional proteins, including TGF-βs, activins, and bone morphogenetic proteins (BMPs).4 They regulate cellular proliferation, differentiation, migration, and ECM production.4 Through these functions, TGF-β is known to regulate the wound healing process in many tissue. For example, TGF-β accelerates the abnormal …

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