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Candida glabrata endophthalmitis following penetrating keratoplasty
  1. FIONA M CHAPMAN
  1. Department of Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP
  2. Department of Microbiology, Freeman Hospital, Newcastle upon Tyne NE7 2DN
  3. Department of Ophthalmology, Bristol Eye Hospital, Bristol BS1 2LX
  4. Department of Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP
  1. KATHERINE E ORR
  1. Department of Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP
  2. Department of Microbiology, Freeman Hospital, Newcastle upon Tyne NE7 2DN
  3. Department of Ophthalmology, Bristol Eye Hospital, Bristol BS1 2LX
  4. Department of Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP
  1. W JOHN ARMITAGE,
  2. DAVID L EASTY
  1. Department of Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP
  2. Department of Microbiology, Freeman Hospital, Newcastle upon Tyne NE7 2DN
  3. Department of Ophthalmology, Bristol Eye Hospital, Bristol BS1 2LX
  4. Department of Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP
  1. DAVID G COTTRELL
  1. Department of Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP
  2. Department of Microbiology, Freeman Hospital, Newcastle upon Tyne NE7 2DN
  3. Department of Ophthalmology, Bristol Eye Hospital, Bristol BS1 2LX
  4. Department of Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP
  1. D G Cottrell.

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Editor,—Transmission of infection by donor tissue is a well known, albeit rare, complication of corneal transplantation.1 We have found two reports2 3 of Candida glabrataendophthalmitis, one with an organ cultured cornea when systemic antifungal treatment contributed to the patient’s death.2

CASE REPORT

A 43 year old man with keratoconus had two previous right corneal grafts. The first, in 1974, became vascularised and oedematous after several months; the second, in 1990, failed after two rejection episodes. In February 1995 he underwent further right penetrating keratoplasty using tissue typed material, stored in organ culture for 20 days and transport medium (5% dextran) for 2 days. On the first postoperative day UK Transplant Support Service Authority reported culture of a yeast from the transport medium, subsequently identified as Candida glabrata. Clinically the graft was satisfactory but topical econozole 1% (in arachis oil) was given …

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