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Editor,—Cytomegalovirus (CMV) retinitis predominantly occurs in severely immunocompromised patients with CD4+ counts below 50 cells ×106/l. Before the use of combinations of protease inhibitors and other antiretroviral agents, CMV retinitis invariably progressed in the absence of specific anti-CMV therapy. This highly active antiretroviral therapy (HAART) can decrease human immunodeficiency virus (HIV) load and increase CD4 T cell counts in patients with AIDS.1 2 In this study we describe two patients receiving HAART, who present with probable inactive CMV retinitis although they never received anti-CMV therapy. In one of these patients, CMV retinitis recurred shortly after his CD4+ cell counts fell below 50 cells ×106/l despite continued combination antiretroviral therapy.
case reports
Patient No 1
A 28 year old man with AIDS and a history of one positive blood culture for CMV and a CD4+ cell count of 13 …