Article Text

Download PDFPDF

Anti-GQ1b ganglioside antibody and ophthalmoplegia of undetermined cause
  1. Tone Suzukia,
  2. Atsuro Chibab,
  3. Susumu Kusunokib,
  4. Makoto Chikudaa,
  5. Tsuneaki Fujitaa,
  6. Kazuo Misua
  1. aDepartment of Ophthalmology, Dokkyo University School of Medicine, Koshigaya Hospital, Saitama, Japan, bDepartment of Neurology, University of Tokyo, Tokyo, Japan
  1. Tone Suzuki, MD, Department of Ophthalmology, Dokkyo University School of Medicine, Koshigaya Hospital, 2-1-50 Minamikoshigaya, Koshigaya, Saitama, 343-8555, Japan.


BACKGROUND/AIM Serum antibody against ganglioside GQ1b is reported to be closely associated with immune mediated ophthalmoplegia in the Fisher and Guillain-Barré syndromes. Its presence against glycolipids, in particular ganglioside GQ1b, was investigated in patients with ophthalmoplegia of unknown origin.

METHODS 16 patients with ophthalmoplegia, the cause of which could not be confirmed from clinical findings or diagnostic testing, were tested. 34 patients who had ophthalmoplegia of definite cause, 16 healthy people, and 23 patients with typical Fisher syndrome served as the controls. The ELISA was used to check for serum antibodies against glycolipids in all study participants.

RESULTS Two of the 16 patients with ophthalmoplegia of unknown cause had serum IgG antibody against GQ1b but not against other glycolipids, and 22 of the 23 patients with typical Fisher syndrome had this antibody. No anti-GQ1b antibodies were found in the patients with ophthalmoplegia of definite cause or in the normal controls.

CONCLUSION A common underlying cause appears to bring about the pathogenesis of palsy in Fisher syndrome and in the ophthalmoplegia with positive anti-GQ1b IgG antibody, called atypical Fisher syndrome. This antibody may prove a useful clinical marker for differentiating Fisher syndrome, typical and atypical, in patients with ophthalmoplegia.

  • GQ1b ganglioside
  • Fisher syndrome
  • Guillain-Barré syndrome
  • ophthalmoplegia
View Full Text

Statistics from


    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.