Article Text

Download PDFPDF

“New” surgical treatments for glaucoma
  1. P T KHAW,
  1. Glaucoma and Wound Healing Research Units, Department of Pathology, Institute of Ophthalmology and Moorfields Eye Hospital, London EC1V 9EL

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    In the beginning of 1998 many ophthalmologists in the United Kingdom received inquiries from their patients with glaucoma about a “new” operation for glaucoma. These inquiries were the result of an article in the popular press, which featured a patient who had undergone non-penetrating sclerostomy with a collagen wick device.1 2 Ophthalmologists in the United States also had a similar experience when an article appeared in a popular Sunday colour supplement, with some glaucoma patients actually demanding the procedure from their specialist based on the article (HA Quigley, 1998, personal communication). It was difficult to advise patients based on facts, as a search of the literature at the time revealed very little published on the results of this procedure (in commonly quoted peer reviewed journals) with a significant follow up period.

    Therefore, it will be very useful for ophthalmologists that Karlen and colleagues have reported in this issue of theBJO (p 6) the medium term results of this procedure in a large group of white patients. The majority of these patients appear to be in groups that have a relatively low risk of filtration surgery failure as a result of scarring. This study helps to give us an idea where this procedure stands in relation to the gold standard which is Cairns type guarded filtration surgery (trabeculectomy).

    The idea of producing a non-penetrating sclerectomy is not new and has a long history (A Bechetoille, 1998, personal communication). Contributors include Zimmerman et al who published some early results with non-penetrating sclerectomy in the early 1980s3 4 and Arenas.5 Koslovet al developed the technique in the current paper where the deep dissection was moved forward to Descemet’s membrane and they proposed an additional collagen implant as well as the term “deep sclerectomy”.6 Subsequently, in collaboration with a manufacturer (Staar Surgical AG, Switzerland), a collagen implant was developed and promotion of the process began in Europe (the Food and Drug Administration had not yet approved the implant in the United States). This implant then began to be used in France7 and subsequently in other European centres (see Karlen et al, p 6).

    The main apparent advantages of the non-penetrating sclerostomy over conventional trabeculectomy rely on the fact that the globe is not penetrated during the procedure as a thin layer of trabecular meshwork tissue is left. This should result in less early postoperative hypotony and associated complications such as choroidal effusion and, possibly, inflammation. It is possible that a reduction in inflammation may also result in less cataract progression, which would be a very significant advantage, particularly in the context of filtration surgery in developing countries. The group of patients that might benefit particularly from a reduction in postoperative shallow anterior chambers would be patients with narrow angle glaucoma who are liable to develop flat anterior chambers and malignant glaucoma. Unfortunately, this procedure is relatively contraindicated in this group of patients, and malignant glaucoma may still occur after non-penetrating sclerostomy as described by Karlen et al. As the eye is not penetrated, no peripheral iridectomy is performed and this results in less hyphaema as no intraocular tissue is actually cut. In theory, these advantages should lead to a shorter visual rehabilitation period for the patient which would be very important if confirmed. It has also been suggested that the collagen implant itself may retard fibrosis although in the present study subconjunctival 5-fluorouracil was used in 23% of the patients. The deep sclerectomy seems to produce more diffuse, less cystic, blebs which may be due in part to deep drainage. This may result in a reduced incidence of long term endophthalmitis.

    There are also, however, potential disadvantages to the described procedure. There was a definite learning curve. The major intraoperative complication is said to be inadvertent perforation of the trabecular meshwork, in which case the operation has to be converted to a standard trabeculectomy. This may potentially result in a suboptimal trabeculectomy as a larger scleral space has been cleared and this may possibly lead to overdrainage if the scleral flap cannot be well secured over this large sclerectomy area. The incidence of short term hypotony was 90% if the operation had to be converted to trabeculectomy.8 The remaining trabecular tissue has to be very thin to achieve flow as it may be necessary to remove the external trabecular tissue where it is thought the majority of the flow resistance is located.9 Inevitably, this requires a learning curve and, in this study, iatrogenic perforation of the trabecular meshwork membrane occurred in 30% of the first 10 sclerectomies and subsequently only 3% of the subsequent 96 procedures. This is in a centre where this procedure was performed on a large number of patients. It could be expected that perforation would occur more commonly if surgeons were carrying out this procedure less frequently. The other problem of leaving this thin membrane is the fact that the membrane then needs to be perforated. A high percentage of patients in the current study (41%) required goniopuncture with the Nd:YAG laser. This suggests that even in such experienced hands, it is often not possible to dissect down to a thin enough layer so that further goniopuncture is not required. Other potential disadvantages may lie with the use of the collagen implant. The implant is expensive and is sold in Switzerland for approximately $US200 (£120) which is a significant addition to the cost of filtration surgery. This additional cost may be justified, but only if it can be proved that it provides advantages which make up for this cost. The implant is made out of lyophilised American porcine scleral collagen that is sterilised by irradiation. Although it is claimed that this material does not induce a systemic reaction, it is still a device which has biological foreign material and therefore there is always a possibility of a long term immunological reaction. This may result in the long term loss of pressure control because of scarring. Furthermore, although viral and bacterial contamination can be removed with current processes, at present there is no process that is known to remove prion particles from biological material. Fortunately, the chance of this sort of contamination is extremely small.

    Although the collagen implant appears to be an integral part of this procedure and there is evidence that the procedure may be better with the implant,10 there is also evidence that this operation may work just as well without a collagen implant if combined with a single inexpensive intraoperative application of 5-fluorouracil on a sponge.11 Combination with intraoperative mitomycin C may improve intraocular pressure control, although great care would have to be taken to prevent significant intraocular penetration.

    Finally, what about the degree of intraocular pressure control? The qualified success rate (intraocular pressure lower than 21 mm Hg on medications) was a very good 97.7% at 36 months. However, the complete success rate (IOP less than 21 mm Hg without medication), which is perhaps a better reflection of the more stringent targets for intraocular pressure control we now aim for, was only 44.6%. This appears a little low for surgery combined with subconjunctival 5-fluorouracil in a quarter of patients. The degree of pressure control may ultimately decide the place of deep sclerectomy, with increased recognition that lower intraocular pressures are required to prevent glaucoma progression.12

    So what will be the place of deep sclerectomy with or without collagen implant in our repertoire of glaucoma surgery in the next millennium? It may be useful to take a short look back in history to give us some perspective. The Cairns trabeculectomy was very rapidly taken up by the ophthalmological community because of its very significantly increased safety margin compared with full thickness unguarded sclerostomy. The difference in complications, particularly flat anterior chambers, was so dramatic that this operation rapidly became the gold standard, and has been ever since. This clearly will not be the case with non-penetrating sclerostomy, because modern filtration surgery, with techniques including releasable sutures, means that the difference between deep sclerectomy with collagen implant and current filtration surgery will be more marginal. Other techniques of filtration surgery have also been previously proposed such as laser sclerostomy which was theoretically faster, more convenient, and provoked less scarring response because it was minimally invasive. Unfortunately, it has not lived up to its early promise. However, it is important not to be too dismissive. It should be remembered that the use of intraoperative mitomycin C was first pioneered by Chen in the early 1980s.13 It was only taken up with enthusiasm in the late 1980s and has now, despite significant complications, swept across the field of glaucoma like very few other techniques and has certainly revolutionised the treatment of many difficult patients.

    In conclusion, the Lausanne group are to be commended for producing this report which begins to provide the type of data that is needed to make rational judgments about the place for this procedure in the management of glaucoma. Clearly, much more data are required for us to make definitive decisions about the exact role of this procedure in the management of glaucoma. There are other interesting procedures also receiving publicity in the literature such as viscocanalostomy14 (which also involves a deep sclerectomy) and direct trabecular aspiration.15 Further basic research is needed to determine the actual routes of outflow with deep sclerectomy. It is possible this may provide new insights into alternative methods of enhancing aqueous outflow and reducing intraocular pressure. Only long term follow up data and randomised long term prospective trials comparing “new” procedures against the gold standard of trabeculectomy will help us to establish the role of these procedures in the management of glaucoma in the future. In the meantime, ophthalmologists are urged to approach new procedures with caution and care and to continually audit their results.


    PTK and DS are supported by the Medical Research Council (UK)


    Linked Articles