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Scientific correspondence
Corneal wound healing following laser in situ keratomileusis (LASIK): a histopathological study in rabbits
  1. Takuji Kato,
  2. Kiyoo Nakayasu,
  3. Yuji Hosoda,
  4. Yasuo Watanabe,
  5. Atsushi Kanai
  1. Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan
  1. Takuji Kato, MD, Department of Ophthalmology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Abstract

AIMS To investigate the histopathological changes of rabbit corneas after laser in situ keratomileusis (LASIK) and to evaluate the corneal wound healing process.

METHODS A LASIK was performed on white rabbit eyes. Postoperatively, rabbits were killed on days 1 and 7, and at 1, 3, and 9 months.

RESULTS Periodic acid Schiff (PAS) positive material and disorganised collagen fibre were seen along the interface of the corneal flap even 9 months after operation.

CONCLUSIONS The wound healing process still continued at 9 months after LASIK indicating that a much longer time than expected was required for corneal wound healing following LASIK.

  • corneal wound healing
  • laser
  • keratomileusis
  • refractive surgery

https://doi.org/10.1136/bjo.83.11.1302

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