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Herpes simplex virus (HSV-1) infection in a donor cornea
  1. U SENGLER,
  2. H SPELSBERG,
  3. T REINHARD,
  4. R SUNDMACHER
  1. Eye Hospital, Heinrich-Heine-University, Düsseldorf, Germany
  2. Medical Microbiology and Virology, Heinrich-Heine-University, Düsseldorf, Germany
  3. Eye Hospital, Albert-Ludwigs-University, Freiburg, Germany
  1. O ADAMS
  1. Eye Hospital, Heinrich-Heine-University, Düsseldorf, Germany
  2. Medical Microbiology and Virology, Heinrich-Heine-University, Düsseldorf, Germany
  3. Eye Hospital, Albert-Ludwigs-University, Freiburg, Germany
  1. C AUW-HAEDRICH,
  2. H WITSCHEL
  1. Eye Hospital, Heinrich-Heine-University, Düsseldorf, Germany
  2. Medical Microbiology and Virology, Heinrich-Heine-University, Düsseldorf, Germany
  3. Eye Hospital, Albert-Ludwigs-University, Freiburg, Germany
  1. U Sengler, MD, Eye Hospital, Heinrich-Heine-University, Moorenstrasse 5, D-40225 Düsseldorf, Germany

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Editor,—According to polymerase chain reaction (PCR) studies1 up to 20% of organ culture donor corneas may contain herpes simplex virus (HSV) DNA. Only five HSV donor cornea infections, however, have been reported worldwide1-3 (J Garweg, M Böhnke, personal communication). In only one of the five cases published so far the infection was transmitted to the recipient.1 The other four corneas showed severe endothelial damage and were discarded before transplantation.1 2 It is likely therefore that the whole virus must be present at the time of donor retrieval to result in subsequent transmission of disease …

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