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Kimura’s disease: no evidence of clonality
  1. C S CHIM
  1. University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
  2. University Department of Pathology, Queen Mary Hospital, University of Hong Kong, Hong Kong
  3. University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
  1. W H SHEK
  1. University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
  2. University Department of Pathology, Queen Mary Hospital, University of Hong Kong, Hong Kong
  3. University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
  1. R LIANG,
  2. Y L KWONG
  1. University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
  2. University Department of Pathology, Queen Mary Hospital, University of Hong Kong, Hong Kong
  3. University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
  1. Dr C S Chim, University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong.

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Editor,—Kimura’s disease is a chronic inflammatory disorder of unknown aetiology.1 Patients usually present with recurrent painless swellings in the subcutis of the head and neck region, increased serum IgE levels, and peripheral eosinophilia. The disease is described as reactive and data on clonality is absent.

Here we describe a patient with Kimura’s disease involving the orbits. Clonality studies were performed by polymerase chain reaction (PCR) for immunoglobulin heavy chain (IgH), T cell receptor gamma (TCR-γ), and delta (TCR-δ) gene rearrangements.2-4

CASE REPORT

A 20 year old man presented with a 2 × 3 cm right eyelid swelling in 1986 with normal visual acuity and absence of diplopia. In 1993, he presented with progressive swelling in the right upper eyelid, which subsided with a short course of prednisolone (50 mg/day × 1 week). He was lost to follow up until May 1997 when he developed recurrent swelling of …

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