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Editor,—Ligneous conjunctivitis is a rare chronic pseudomembranous conjunctivitis that in some cases is associated with membrane formation in other mucous tissues. Involvement of the palpebral conjunctiva is the most common site of the disease although formation of bulbar membrane and even corneal membrane have been reported.1 Induction of membrane formation may occur after minor trauma (for example, conjunctivitis, surgery, toxic agents).
The disorder has an AR inheritance and is caused by an impaired fibrinolysis related to deficient plasminogen type I. Recently causative mutations in the plasminogen gene have been identified in affected patients.2
Pathological findings disclose fibrin as the major component within amorphous hyalin-like eosinophilic material, fibroblastic proliferation, inflammatory cellular infiltration, and acid mucopolysaccharides.3
The treatment of the disorder has generally been unsuccessful, although spontaneous resolution may …