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Editor,—Voriconazole is a new, highly potent, triazole with broad spectrum activity against fungi, including moulds as well as fluconazole resistant Candidaspp.1 Like other azole antifungal agents it interferes with ergosterole biosynthesis. Its antifungal activity has been shown in several experimental as well as clinical studies.2-5
CASE REPORT
In November 1998, a 16 year old girl was transferred to the university eye hospital in Duesseldorf with a severe ulcerative hypopyon keratitis in the left eye, from which she had been suffering for 3 months after swimming in a lake in Italy. Smears, scrapings, and serology gave no hint of the aetiology. Despite intensive topical antibacterial, anti-acanthamoebal, antifungal, and antiherpetic therapy, as well as cryoapplication, her clinical situation had deteriorated continuously before admission to our hospital. As an optical rehabilitation was unlikely, owing to the severely …