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Editor,—I read with interest the paper by Weinberger et al.1 In this pilot study about ICGA guided photocoagulation of occult choroidal neovascularisation (CNV) in AMD, the authors provide evidence for a beneficial effect on visual prognosis by treating this CNV pattern. However, some issues can be raised about both inclusion criteria and patients' selection and then about results.
On ICGA, all eyes included in the study show a choroidal neovascular network, with CNV size smaller than four disc areas; the authors do not specify how many hot spots, plaques, or mixed lesions are in their sample. Indications for treatment, visual prognosis, and recurrence rate in these three CNV morphological types are quite different.2
Furthermore, a marked disproportion between eyes with pigment epithelial detachment (PED) (two cases) and those without PED (the remaining 19), not reflecting the data provided by Guyer and colleagues in 1000 consecutive eyes,3 characterises the examined population. The authors present the final …
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