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Amniotic membrane graft for primary pterygium: comparison with conjunctival autograft and topical mitomycin C treatment
  1. David Hui-Kang Maa,
  2. Lai-Chu Seeb,
  3. Su-Bin Liaua,
  4. Ray Jui-Fang Tsaia
  1. aDepartment of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, bDepartment of Public Health, College of Medicine, Chang Gung University, Taoyuan, Taiwan
  1. Ray Jui-Fang Tsai, 2F 350 Section 4 Cheng Kung Road, Taipei, Taiwan, 114raytsai{at}


AIM To study the efficacy and safety of amniotic membrane graft as an adjunctive therapy after removal of primary pterygium, and to compare the clinical outcome with conjunctival autograft and topical mitomycin C.

METHODS 80 eyes of 71 patients with primary pterygia were treated with excision followed by amniotic membrane graft. The result was compared retrospectively with 56 eyes of 50 patients receiving conjunctival autograft, and 54 eyes of 46 patients receiving topical mitomycin C. Patients were followed for at least 6 months, and the averaged follow up periods for the three groups were 13.8, 22.8, and 18.4 months, respectively.

RESULTS There were three recurrences (3.8%) in the amniotic membrane graft group, three recurrences (5.4%) in the conjunctival autograft group, and two recurrences (3.7%) in the topical mitomycin C group. There was no significant difference in recurrence rate among the three groups (p = 0.879). No major complications occurred in the amniotic membrane graft group or the conjunctival autograft group. One case of infectious scleritis due to scleral ischaemia occurred in the topical mitomycin C group.

CONCLUSION This study showed that amniotic membrane graft was as effective as conjunctival autograft and mitomycin C in preventing pterygium recurrence, and can be considered as a preferred grafting procedure for primary pterygium.

  • pterygium
  • amniotic membrane
  • conjunctival autograft
  • mitomycin C
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