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Varicella zoster virus immune recovery stromal keratitis in a patient with AIDS
  1. The Francis I Proctor Foundation and the Department of Ophthalmology, UCSF, Medical Center
  2. San Francisco, USA
  1. Dr Todd P Margolis, The Francis I Proctor Foundation, UCSF, Medical Center, San Francisco, CA, 94143-0944, USA tpms{at}

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Editor,—The advent of potent antiretroviral therapy has resulted in the recognition of the syndrome of immune recovery uveitis in patients with AIDS and a history of cytomegalovirus (CMV) retinitis.1 Although the pathogenesis of this disease is poorly understood, it is hypothesised to be a consequence of an improved immune response to viral antigen already present in the eye, with or without active viral replication.2 We describe a case of immune recovery varicella zoster virus (VZV) stromal keratitis in a patient with AIDS.


A 37 year old man with AIDS (CD4 = 180 cells × 106/l) developed right sided ophthalmic zoster and was treated with aciclovir (800 mg by mouth five times a day). Twelve days after onset …

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