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Relation between macular morphology and visual function in patients with choroidal neovascularisation of age related macular degeneration
  1. Nuala Dorisa,
  2. Patricia M Hartb,
  3. Usha Chakravarthyb,
  4. Julie McClelanda,
  5. Michael Stevensonc,
  6. Chris Hudsona,
  7. Jonathan Jacksonb
  1. aSchool of Biomedical Science, University of Ulster, bOphthalmology and Vision Science Queen's University of Belfast, cHealth and Health Care Research, Queen's University of Belfast
  1. Usha Chakravarthy, Ophthalmology and Vision Science, Queen's University and Royal Victoria Hospital, Belfast BT12 6BA, UKu.chakravarthy{at}


AIM To examine the relation between three measures of visual function (distance acuity, near acuity, and contrast sensitivity) and specific fluorescein angiographic characteristics of the macular lesion in patients with subfoveal choroidal neovascularisation (CNV) due to age related macular degeneration (AMD).

METHODS Visual evaluation and digital fundus fluorescein angiography were performed in 93 patients with subfoveal CNV. Standard morphometric techniques were used on two frames from the angiographic series closest to 30 seconds and 60 seconds respectively, to ascertain total lesion size (defined as the entire area of abnormal fluorescence), the size of the classic component, and the distance from the fovea to the closest point of healthy retina. Correlations were sought using Pearson's correlation coefficients. Stepwise regression was used to minimise multiple colinearity.

RESULTS When the study eye was the better eye of a patient's pair of eyes, the strongest correlation was between the size of the classic component and contrast sensitivity (r= 0.48, p <0.001) and was highly significant. When the study eye was the worse eye, significant correlations were observed between total lesion size and all three measures of visual function. The strongest correlation was observed between overall lesion size and contrast sensitivity (r = 0.52, p <0.001).

CONCLUSIONS This study has shown that the status of the study eye (that is, better or worse eye of a pair of eyes) influences the impact of macular pathology in AMD on visual function. The distance of the fovea from healthy retina was found to be an important factor in predicting visual function.

  • fluorescein angiography
  • visual function
  • age related macular degeneration
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