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Bilateral granulomatous uveitis in association with common variable immunodeficiency
  1. VICTORIA M L COHEN
  1. Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
  2. Department of Pathology
  3. Department of Clinical Immunology, Northern General Hospital, Sheffield S5 7YT, UK
  4. Department of Medicine, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
  5. Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
  1. JOHN A LEE
  1. Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
  2. Department of Pathology
  3. Department of Clinical Immunology, Northern General Hospital, Sheffield S5 7YT, UK
  4. Department of Medicine, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
  5. Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
  1. WILLIAM EGNER
  1. Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
  2. Department of Pathology
  3. Department of Clinical Immunology, Northern General Hospital, Sheffield S5 7YT, UK
  4. Department of Medicine, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
  5. Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
  1. MOIRA K B WHYTE
  1. Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
  2. Department of Pathology
  3. Department of Clinical Immunology, Northern General Hospital, Sheffield S5 7YT, UK
  4. Department of Medicine, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
  5. Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
  1. IAN G RENNIE
  1. Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
  2. Department of Pathology
  3. Department of Clinical Immunology, Northern General Hospital, Sheffield S5 7YT, UK
  4. Department of Medicine, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
  5. Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
  1. Miss Victoria Cohen, Department of Ophthalmology, Box 41, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK victoria-cohen{at}supanet.com

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Editor,—We report a case of bilateral granulomatous uveitis, which prompted extensive diagnostic review in a 20 year old woman with a long history of recurrent infection and idiopathic thrombocytopenia. Investigations allowed the definitive diagnosis of common variable immunodeficiency with granulomas (granulomatous antibody deficiency syndrome.) To our knowledge this is the first reported case of granulomatous uveitis in association with granulomatous antibody deficiency (GAD). We discuss the features of GAD, and how it may be distinguished from sarcoidosis.

CASE REPORT

A 20 year old woman presented with sudden onset blurred vision. Examination revealed a bilateral granulomatous uveitis with mutton-fat keratic precipitates and anterior chamber cells. Two weeks later she developed bilateral optic disc swelling with multifocal areas of choroidal pallor in her left eye (Fig 1). There was no vitritis …

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