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The tubulointerstitial nephritis and uveitis (TINU) syndrome is associated with HLA-DR14 in Spanish patients
  1. MARINA B GORROÑO-ECHEBARRÍA,
  2. MIGUEL A CALVO-ARRABAL,
  3. FERNANDO ALBARRÁN,
  4. MELCHOR ALVAREZ-MON
  1. Departments of Ophthalmology and Diseases of the Immune system, Hospital Universitario “Príncipe de Asturias” (Alcalá de Henares)
  1. mbgech{at}netscape.net

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Editor,—An uncommon association between tubulointerstitial nephritis and anterior uveitis was described in two adolescent female patients with non-caseating granulomas in both bone marrow and lymph nodes by Dobrin1 and is referred to as TINU syndrome. Since then, some 50 cases (35 paediatric patients and 15 adults) have been described. Its distribution is typically in young girls aged 10–14 years. The kidneys are affected by tubulointerstitial nephritis with predominant mononuclear infiltrate in the majority of cases. The ocular lesion invariably consists of anterior uveitis and, exceptionally, panuveitis. Although the aetiology is still unknown, the laboratory findings reported suggest that TINU is a cell mediated immune disease.2 Genetic markers (HLA alleles) have also been implicated as susceptibility risk factors.3

CASE REPORT

We describe the cases of three further …

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