Article Text

Download PDFPDF
Incidence of iris colour change in latanoprost treated eyes
  1. M A Teus1,2,
  2. E Arranz-Márquez1,
  3. P Lucea-Suescun1
  1. 1Department of Ophthalmology, “Príncipe de Asturias” Hospital, University of Alcalá, Alcalá de Henares, Madrid, Spain
  2. 2Hospital Oftalmológico Internacional de Madrid
  1. Correspondence to: Miguel A Teus, MD, PhD, Emiliano Barral 14-B, 1-A, 28043 Madrid, Spain; mteus{at}


Aims: To determine the incidence of increased iris pigmentation in eyes treated with chronic latanoprost. This is an observational, cohort study.

Methods: The anterior segments of both eyes of 43 patients with glaucoma were photographed after unilateral latanoprost therapy. Two independent, masked observers analysed the slides of both eyes of the study participants, and compared the iris pigmentation of both eyes of each patient using a stereo viewer.

Results: 30 patients (69.7%) had a definite acquired iridial anisochromia; 15 patients (50%) had increased superficial iris pigmentation with a “granular” appearance (type 1 change), and 15 patients (50%) had an increased “stromal pigmentation”—that is, the affected iris appeared darker than the fellow eye, but without a “granular” appearance (type 2 change).

Conclusion: The incidence of increased iris pigmentation induced by latanoprost is much higher than previously reported. The high prevalence of mixed iris colour found in this population and the fact that the patients studied were undergoing unilateral therapy may explain these results.

  • iris colour
  • latanoprost

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • The authors have no proprietary interest in any aspect of this study.

Linked Articles

  • BJO at a glance
    Creig Hoyt