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Incidence of ROP in two consecutive Swedish population based studies
  1. E Larsson1,
  2. B Carle-Petrelius2,
  3. G Cernerud3,
  4. L Ots4,
  5. A Wallin5,
  6. G Holmström1
  1. 1Department of Ophthalmology, University Hospital, Uppsala, Sweden
  2. 2St Erik’s Eye Hospital, Karolinska Institute, Stockholm, Sweden
  3. 3Södersjuk huset, Stockholm, Sweden
  4. 4Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden
  5. 5Danderyds Hospital, Stockholm, Sweden
  1. Correspondence to: Gerd Holmström, MD, PhD, Department of Ophthalmology, University Hospital, S 758 95 Uppsala, Sweden; gerd.holmstrom{at}


Aims: To prospectively analyse the present incidence of ROP (retinopathy of prematurity) in a well defined geographical area in Sweden, and to compare it with that from a decade earlier in exactly the same area.

Methods: Infants born between 1 August 1998 and 31 July 2000 with a birth weight of 1500 g or less were studied. They were screened for ROP from 5 weeks of postnatal age until the retina was entirely vascularised. The incidence of ROP, with its various stages, was compared with that of a previous (1988–90) population based study in the same geographical area.

Results: The incidence of ROP in the present study was 36.4% (mild (18.2%) and severe ROP (18.2%)), which was similar to that of the previous study. Gestational age at birth remained the most important risk factor for ROP. We found a change in the distribution of ROP. The probability of ROP, particularly severe ROP, was highest in the most immature infants while it was lower in the least immature ones.

Conclusions: The incidence of ROP remained the same in two consecutive population based studies. The more “mature” infants developed ROP, particularly severe ROP, less often, while the most immature infants had ROP more often, particularly severe ROP.

  • retinopathy of prematurity
  • Sweden

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