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“Amedeo continues to divide his time between his houses in Co Meath and Rome. Until he was 86, he rode to hounds following their hair-raising chases across the Meath countryside, where every field division is a wide ditch. He still keeps two horses, and was recently given two delightful, but time-consuming, Arab fillies—a rarity in Ireland. He rides occasionally, and once in the saddle the aches and pains of age and old wounds disappear. As for the problem of his cataracts, “the horse can see perfectly well for me.” (


There is no treatment on the market today that has been proved to slow the normal human ageing process. However, one intervention has been consistently shown to retard the ageing process in experimental animals and human—-calorie restriction. Regrettably, to achieve the maximum benefit people would probably have to reduce their caloric intake by roughly 30% or the equivalent of no more than 1700 calories per day. Investigators have demonstrated that the benefits of caloric restriction on the ageing process may be mimicked by the use of 2-deoxy-d-glucose (2DG). Unfortunately 2DG appears to be toxic at high levels. A new candidate drug that mimics caloric restriction is iodoacetate, which is being investigated at MIA’s laboratory of neurosciences. If scientists can successfully develop non-toxic agents that …

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