Rapid mutation detection by the Transgenomic wave analyser DHPLC identifies MYOC mutations in patients with ocular hypertension and/or open angle glaucoma

C J Cobb; G Scott; R J Swingler; S Wilson; J Ellis; C J MacEwen; W H I McLean

doi:10.1136/bjo.86.2.191

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Original Article

Rapid mutation detection by the Transgenomic wave analyser DHPLC identifies MYOC mutations in patients with ocular hypertension and/or open angle glaucoma

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	Abstract	Full	Pdf
Jan 2002	18	26	9
Feb 2002	36	119	31
Mar 2002	4	54	12
Apr 2002	6	52	13
May 2002	4	20	8
Jun 2002	3	26	20
Jul 2002	2	22	6
Aug 2002	3	33	10
Sep 2002	4	25	10
Oct 2002	1	20	2
Nov 2002	0	19	5
Dec 2002	0	15	6
Jan 2003	3	14	7
Feb 2003	1	22	17
Mar 2003	0	17	15
Apr 2003	1	26	18
May 2003	1	20	15
Jun 2003	6	15	10
Jul 2003	6	22	20
Aug 2003	18	33	14
Sep 2003	15	35	12
Oct 2003	20	34	5
Nov 2003	19	32	9
Dec 2003	14	30	13
Jan 2004	18	43	18
Feb 2004	9	24	11
Mar 2004	20	28	9
Apr 2004	18	35	14
May 2004	41	72	19
Jun 2004	46	70	21
Jul 2004	47	65	16
Aug 2004	40	59	13
Sep 2004	24	53	21
Oct 2004	10	48	30
Nov 2004	6	48	11
Dec 2004	5	47	16
Jan 2005	10	32	17
Feb 2005	9	39	12
Mar 2005	6	19	9
Apr 2005	2	19	15
May 2005	4	24	26
Jun 2005	7	31	18
Jul 2005	4	21	8
Aug 2005	18	34	14
Sep 2005	24	25	14
Oct 2005	28	33	19
Nov 2005	26	31	33
Dec 2005	13	21	14
Jan 2006	13	28	12
Feb 2006	21	21	9
Mar 2006	10	32	14
Apr 2006	18	21	16
May 2006	33	20	16
Jun 2006	24	12	15
Jul 2006	12	9	9
Aug 2006	11	13	7
Sep 2006	9	17	10
Oct 2006	14	22	18
Nov 2006	7	23	25
Dec 2006	18	19	9
Jan 2007	12	37	28
Feb 2007	16	23	17
Mar 2007	21	19	16
Apr 2007	18	3	4
May 2007	25	10	8
Jun 2007	22	7	6
Jul 2007	12	9	13
Aug 2007	18	7	5
Sep 2007	14	3	5
Oct 2007	12	5	9
Nov 2007	14	4	8
Dec 2007	7	4	4
Jan 2008	21	4	4
Feb 2008	16	3	4
Mar 2008	12	1	3
Apr 2008	16	2	5
May 2008	20	5	4
Jun 2008	10	6	0
Jul 2008	22	1	1
Aug 2008	17	8	3
Sep 2008	23	3	2
Oct 2008	25	4	6
Nov 2008	22	1	1
Dec 2008	14	5	3
Jan 2009	17	3	1
Feb 2009	22	1	3
Mar 2009	18	3	6
Apr 2009	8	2	1
May 2009	17	4	2
Jun 2009	28	4	4
Jul 2009	14	2	2
Aug 2009	5	0	3
Sep 2009	9	1	1
Oct 2009	15	3	7
Nov 2009	10	1	4
Dec 2009	8	2	2
Jan 2010	5	0	0
Feb 2010	8	1	3
Mar 2010	12	2	2
Apr 2010	6	5	0
May 2010	6	0	3
Jun 2010	15	3	6
Jul 2010	9	3	2
Aug 2010	7	3	1
Sep 2010	15	1	2
Oct 2010	16	7	1
Nov 2010	11	7	5
Dec 2010	6	8	0
Jan 2011	19	6	0
Feb 2011	14	0	0
Mar 2011	4	12	3
Apr 2011	4	25	0
May 2011	7	9	6
Jun 2011	10	0	0
Jul 2011	9	0	2
Aug 2011	7	2	0
Sep 2011	4	2	2
Oct 2011	14	5	12
Nov 2011	11	6	1
Dec 2011	15	5	10
Jan 2012	15	7	11
Feb 2012	13	3	8
Mar 2012	0	1	4
Apr 2012	5	10	9
May 2012	15	8	3
Jun 2012	11	8	11
Jul 2012	9	4	7
Aug 2012	11	9	5
Sep 2012	1	8	6
Oct 2012	9	41	7
Nov 2012	15	21	3
Dec 2012	15	18	5
Jan 2013	25	21	8
Feb 2013	9	6	2
Mar 2013	12	22	3
Apr 2013	14	14	4
May 2013	26	11	4
Jun 2013	8	8	2
Jul 2013	5	12	4
Aug 2013	6	13	2
Sep 2013	2	5	2
Oct 2013	2	28	5
Nov 2013	6	1	1
Dec 2013	4	4	2
Jan 2014	4	2	1
Feb 2014	3	5	2
Mar 2014	10	2	1
Apr 2014	12	5	1
May 2014	10	8	4
Jun 2014	6	6	1
Jul 2014	5	4	1
Aug 2014	6	6	1
Sep 2014	3	5	5
Oct 2014	3	2	2
Nov 2014	11	3	1
Dec 2014	2	5	4
Jan 2015	3	2	1
Feb 2015	9	0	2
Mar 2015	13	2	3
Apr 2015	6	1	1
May 2015	2	4	3
Jun 2015	6	3	0
Jul 2015	6	4	2
Aug 2015	9	2	1
Sep 2015	9	4	2
Oct 2015	2	2	0
Nov 2015	8	0	0
Dec 2015	2	3	1
Jan 2016	4	2	5
Feb 2016	1	1	3
Mar 2016	11	2	6
Apr 2016	2	0	2
May 2016	12	1	2
Jun 2016	3	1	1
Jul 2016	11	4	4
Aug 2016	7	2	1
Sep 2016	13	0	5
Oct 2016	5	1	3
Nov 2016	5	2	1
Dec 2016	4	0	1
Jan 2017	6	2	0
Feb 2017	0	3	1
Mar 2017	0	4	1
Apr 2017	0	10	2
May 2017	2	12	0
Jun 2017	7	14	4
Jul 2017	15	14	1
Aug 2017	13	13	2
Sep 2017	62	62	0
Oct 2017	128	128	0
Nov 2017	49	49	2
Dec 2017	43	41	0
Jan 2018	22	20	1
Feb 2018	31	29	2
Mar 2018	17	15	1
Apr 2018	30	30	0
May 2018	30	25	1
Jun 2018	24	20	0
Jul 2018	26	24	0
Aug 2018	33	31	0
Sep 2018	27	27	1
Oct 2018	41	39	1
Nov 2018	43	43	0
Dec 2018	46	46	2
Jan 2019	41	39	1
Feb 2019	34	30	2
Mar 2019	11	11	4
Apr 2019	5	3	10
May 2019	6	6	4
Jun 2019	24	22	3
Jul 2019	13	12	4
Aug 2019	21	19	5
Sep 2019	15	13	13
Oct 2019	11	11	1
Nov 2019	14	12	5
Dec 2019	19	19	4
Jan 2020	11	11	0
Feb 2020	14	12	4
Mar 2020	13	13	3
Apr 2020	15	12	4
May 2020	15	15	2
Jun 2020	17	17	6
Jul 2020	19	15	0
Aug 2020	34	34	4
Sep 2020	22	17	1
Oct 2020	12	12	4
Nov 2020	6	6	5
Dec 2020	25	16	4
Jan 2021	7	5	4
Feb 2021	4	2	4
Mar 2021	9	7	7
Apr 2021	2	2	1
May 2021	2	2	4
Jun 2021	3	3	0
Jul 2021	8	8	5
Aug 2021	4	3	8
Sep 2021	9	9	5
Oct 2021	12	12	18
Nov 2021	4	4	17
Dec 2021	5	5	1
Jan 2022	10	10	7
Feb 2022	4	4	2
Mar 2022	13	13	3
Apr 2022	9	9	4
May 2022	34	30	17
Jun 2022	22	22	9
Jul 2022	12	12	1
Aug 2022	17	17	3
Sep 2022	21	20	17
Oct 2022	26	26	4
Nov 2022	15	15	12
Dec 2022	15	8	7
Jan 2023	6	6	4
Feb 2023	4	4	3
Mar 2023	4	4	4
Apr 2023	6	4	3
May 2023	5	5	5
Jun 2023	10	10	3
Jul 2023	11	11	4
Aug 2023	8	8	9
Sep 2023	8	8	5
Oct 2023	9	9	1
Nov 2023	13	13	0
Dec 2023	35	2	0
Jan 2024	17	0	0
Feb 2024	5	1	0
Mar 2024	116	1	0
Total	3726	3992	1609

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