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Spontaneous reduction in myopic correction following varicella disciform stromal keratitis
  1. Y F Choong,
  2. N R Hawksworth
  1. Eye Department, Royal Glamorgan Hospital, Ynysmaerdy, Llantrisant, CF72 8XR, UK

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    We present the case of an 11 year old myopic girl who developed significant refractive changes due to corneal scarring following varicella disciform stromal keratitis in her right eye. This has markedly reduced the myopia in her right eye and resulted in significant anisometropia.

    Case report

    This 11 year old girl presented to her general practitioner with a red and painful right eye with reduced vision. She had had an uneventful episode of primary varicella zoster infection (chickenpox) 3 weeks earlier, from which she had made a full recovery. The general practitioner diagnosed her as having conjunctivitis and she was treated with topical chloramphenicol. One week later, the redness and pain had settled but her vision remained hazy. As a result she was referred to the eye department. Examination confirmed a reduction of visual acuity to 6/24 (Snellen) in the right eye and 6/6 in the left with spectacle correction. She was wearing a correction for myopia with a prescription of −4.75/−0.75 × 110° in the right eye and −6.00/−0.50 × 90° in the left eye. There was right superficial disciform stromal scar in the central cornea over the visual axis extending towards the periphery at 6 o’clock. Corneal sensation was intact and equal in both eyes. There was no active inflammation with white conjunctiva and quiet anterior chambers. The intraocular pressures were normal. Fundus examination revealed no abnormality. As there was no active inflammation, she was not given any treatment. On review 2 months later, there was no change in her symptoms or in the clinical findings. One year later, she was seen again in the clinic and has a surprising Snellen visual acuity of 6/9−1 unaided, improving to 6/9+2 with ∞/−1.75 × 150° in the right eye and 6/6 with −7.00 DS in the left. There was a reduction in opacity of the right corneal scar with stromal thinning (Fig 1). There was no ocular inflammation. Corneal topography showed a flattening of the right cornea surface, effectively reducing the degree of myopia in her right eye (Fig 2). This resulted in significant anisometropia and aniseikonia with full corrections to each eye. Despite this she was rather pleased and was coping well without glasses, relying on her “poorer” right eye for distant vision rather than wearing the full myopic correction in her left eye.

    Figure 1

    Anterior segment photograph of the right eye showing mild corneal scarring.

    Figure 2

    Corneal topography of the affected right eye (top) shows a flattening of the corneal surface secondary to disciform stromal corneal scar. Compare this with the unaffected myopic left eye, which has a steeper corneal surface (bottom).


    This is an unusual case of spontaneous myopia correction following corneal scarring secondary to varicella zoster disciform stromal keratitis. Primary varicella zoster infection (chickenpox) is a diffuse vesicular skin rash mainly affecting children and is usually self limiting. Common ocular findings are eyelid vesicles or marginal erosions and acute conjunctivitis.1 Corneal changes are infrequent but can occur during the first week or two after the onset of chickenpox. Disciform stromal keratitis is an unusual but well recognised complication of primary varicella zoster infection.2,3 Varicella viral antigen and intracellular viral inclusions has been found in the corneal epithelium of affected eyes. Wilhemus et al reported five cases and reviewed the literature and found that this condition is typically unilateral, has a delayed onset, typically several weeks after the onset of skin rash.4 The complications following disciform stromal keratitis identified in this review are corneal scarring, neurotrophic keratopathy, iridocyclitis with secondary glaucoma, and iris stromal atrophy. The principal cause of loss of vision is corneal scarring. In our case, the corneal scarring had resulted in the flattening of the corneal surface thus reducing the degree of myopia significantly. This was highly unusual and had contributed to improving the unaided visual acuity in her affected eye. The effect on the cornea was similar to post LASIK (laser assisted in situ keratomileusis) and PRK (photorefractive keratectomy) in that the cornea appearance was similar as was the topography. In addition, the degree of cornea haze was limited and there had been a degree of stability for a period of over 1 year.

    She was unable to tolerate the full refractive corrections because of the significant anisometropia and aniseikonia. Despite this she was pleased as she can see 6/9 unaided and would rather not wear her rather high myopic spectacle correction. In view of her young age, the uncertainty of the long term stability of her refractive state and her lack of visual complaint, contact lens and refractive surgery were not considered as appropriate treatment at present. However, they may have possible roles in her future management.

    Topical corticosteroid therapy and antiviral agents have a role in the management of herpetic stromal disease following herpes simplex and herpes zoster infection.5 However, their roles in the treatment of stromal keratitis following primary varicella zoster are controversial and have not been determined.4 In our patient, the keratitis settled despite having neither topical corticosteroid nor antiviral agent.


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