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Factor XII deficiency and recurrent sixth nerve palsy
  1. A Kipioti,
  2. O C Backhouse,
  3. P M Jacobs,
  4. M R Howard
  1. Department of Ophthalmology, York District Hospital NHS Trust, York, UK
  1. Correspondence to: A Kipioti, Eye Department, Clarendon Wing, Leeds General Infirmary, LS2 9NS, UK; tinakipioti{at}

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Factor XII deficiency is associated with thrombosis.1–3 Severe deficiency increases an individual’s prothrombotic tendency but with a mild reduction in levels there is less certainty.4 We present a case of recurrent sixth cranial nerve palsy due to severe factor XII deficiency. To our knowledge, this is the first reported case of a recurrent cranial nerve palsy associated with factor XII deficiency.

Case report

A 58 year old white male presented with an acquired constant incomitant horizontal diplopia. He had had a previous episode of horizontal diplopia of 3 weeks’ duration 6 months previously with spontaneous resolution and a further similar episode 18 years before that but had been otherwise …

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