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Gene effects in environmentally determined subgroups

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There has been controversy about the usefulness of stratification by environmentally determined subgroups in genetic research. In cancer epidemiology only a few genetic polymorphisms cause a substantial change in risk and many genes involved in the metabolism of mutagens have little or no effect. But the inclusion of environmental measures in genetic studies might reveal environment-gene interactions. Such combined studies have been questioned, however, on the grounds that they are unlikely to increase the power of the genetic study very much. …

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