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Retinoblastoma in a child conceived by in vitro fertilisation
  1. I Lee1,2,
  2. P T Finger1,2,
  3. J A Grifo2,
  4. A R Rausen2,
  5. A Rebarber2,
  6. D H Barad3
  1. 1The New York Eye Cancer Center, New York City, NY, USA
  2. 2New York University School of Medicine, New York City, NY, USA
  3. 3Albert Einstein College of Medicine, New York City, New York, USA
  1. Correspondence to: P T Finger The New York Eye Cancer Center, 115 East 61st Street, New York City, NY 10021, USA;

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As the number of infants born through in vitro fertilisation (IVF) grows, there is increased interest regarding the long term effects of IVF and other assisted reproduction techniques on such offspring. Recent reports have noted cancer in children born after IVF or fertility drug use (table 1).1

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Table 1

 Anomalies and cancers reported in offspring of IVF

In 2001, retinoblastoma was reported to occur in a child born through IVF in Israel.2 Since then, an additional report documented four cases from the Netherlands.3 Here we add a sixth case and the first from the United States. Of these children four had unilateral retinoblastoma and two bilateral disease (table 2).

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Table 2

 Retinoblastoma in children born through IVF

During 2002, a 16 month old child was referred to The New York Eye Cancer Center with no known family history of eye disease. She had a blind painful right eye with neovascular glaucoma. Intraocular pressures were 35 mm Hg in …

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  • Supported by The EyeCare Foundation, Inc and Research to Prevent Blindness, New York City, USA.

  • The authors have no proprietary interest in any material mentioned in this study.