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Dry eye is one of the major symptoms of chronic graft versus host disease (CGVHD).1,2 Although effective therapy for dry eye associated with CGVHD has not been well established, successful treatment with systemic FK506,3,4 topical retinoic acid,5 topical cyclosporin A,6 and topical autologous serum have been reported.7,8 However, improved tear secretion was reported only in one patient with systemic FK506 by Masaoka et al,3 with limited description of ocular findings. We present a patient with dry eye associated with CGVHD, where systemic administration of FK506 resulted in improved ocular surface findings along with the Schirmer test value.
CASE REPORT
A 33 year old man had HLA matched sibling allogeneic peripheral blood stem cell transplantation in December 2000 for acute myeloid leukaemia in remission. He received cyclosporine A as GVHD prophylaxis, but it was …