I read with interest the article by Miyamoto et al.¹ Numerous studies have examined the inter-relation between silicone oil and various ocular structures, such as the retina, iris, or anterior chamber. However, the silicone oil itself was never evident in these studies, but rather small vacuoles suspected to be ghosts of the incorporated silicone oil were apparent. Nevertheless, the vacuoles also could have been artefacts² because silicone, which is solubilised in the organic solvents during the preparation,³ is never detected. We previously demonstrated silicone oil emulsion in the rabbit retina using phthalocyanine blue as …