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Intraocular pressure and systemic blood pressure: longitudinal perspective: the Beaver Dam Eye Study
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  1. B E K Klein,
  2. R Klein,
  3. M D Knudtson
  1. Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI, USA
  1. Correspondence to: Barbara E K Klein MD MPH Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, 610 North Walnut Street, 4th Floor WARF, Madison, WI 53726-2336, USA; kleinbepi.ophth.wisc.edu

Abstract

Aim: To investigate the relation between change in systemic blood pressures and change in intraocular pressure.

Methods: This was a population based study of people 43–86 years old living in Beaver Dam, Wisconsin. Measurements at baseline (1988–90) and 5 year follow up of systemic blood pressures, intraocular pressures, and history of use of blood pressure medications.

Results: Intraocular pressures were significantly correlated with systolic and diastolic blood pressures at both baseline and follow up. There were significant direct correlations between changes in systemic blood pressures and changes in intraocular pressure. There was a 0.21 (95% CI: 0.16 to 0.27) mm Hg increase in IOP for a 10 mm Hg increase in systolic and 0.43 (0.35 to 0.52) mm Hg increase in IOP for a 10 mm Hg increase in diastolic blood pressure. Further adjustment for diabetes and medication use did not alter these associations. Decreased systolic or diastolic blood pressures of more than 10 mm Hg over 5 years were significantly associated with decreased IOP.

Conclusions: Reduced systemic blood pressure is associated with reduced intraocular pressure. This finding should be evaluated in other studies, especially with respect to the possibility of resultant decreased risk of open angle glaucoma.

  • DBP, diastolic blood pressure
  • IOP, intraocular pressure
  • SBP, systolic blood pressure
  • intraocular pressure
  • systemic blood pressure
  • Beaver Dam Eye Study
  • DBP, diastolic blood pressure
  • IOP, intraocular pressure
  • SBP, systolic blood pressure
  • intraocular pressure
  • systemic blood pressure
  • Beaver Dam Eye Study

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Footnotes

  • This study was supported by National Institutes of Health grant EYO6594 (Klein R, Klein BEK).

  • Proprietary or financial interests: None.

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