Article Text

Download PDFPDF
Brinzolamide induced reversible corneal decompensation
  1. J C Zhao,
  2. T Chen
  1. Department of Ophthalmology, Glaucoma Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
  1. Correspondence to: Jing Cheng Zhao MD Progressive Vision Institute, 201 East Laurel Blvd, Pottsville, PA 17901, USA;

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Topical carbonic anhydrase inhibitors (CAIs) such as brinzolamide 1% (Azopt; Alcon Laboratories, Fort Worth, TX, USA) attenuate bicarbonate efflux, and this may lead to corneal oedema.

To our knowledge, this is the first report of complete resolution of corneal oedema after cessation of topical brinzolamide 1%.


A 57 year old African-American man with primary open angle glaucoma (POAG) presented with painless blurry vision left eye 1 hour after instilling brinzolamide 1% in both eyes. He had been on brinzolamide 1% both eyes twice daily, brimonidine tartrate 0.2% (Alphagan) in both eyes twice daily, and latanoprost 0.005% (Xalatan) in both eyes once at night for 2 years. On presentation, best corrected visual acuity (BCVA) was 20/25 right eye and 20/50 left eye. The left eye had mild corneal oedema, Descemet’s folds, and whitish fleck-like debris on the corneal endothelium (fig 1A). Intraocular pressures (IOPs) were …

View Full Text