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Optic disc topographic parameters measured in the normal cynomolgus monkey by confocal scanning laser tomography
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  1. T Taniguchi1,
  2. M Shimazawa2,
  3. M Araie3,
  4. G Tomita3,
  5. M Sasaoka1,
  6. Y Kitazawa4,
  7. H Hara2
  1. 1Research and Development Center, Santen Pharmaceutical Co Ltd, Nara, Japan
  2. 2Department of Biofunctional Molecules, Gifu Pharmaceutical University, Gifu, Japan
  3. 3Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
  4. 4Department of Ophthalmology, Gifu University School of Medicine, Gifu, Japan
  1. Correspondence to: Hideaki Hara PhD, Department of Biofunctional Molecules, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan; hideharagifu-pu.ac.jp

Abstract

Aim: To study optic disc topographic parameters in normal cynomolgus monkeys by Heidelberg retina tomograph (HRT).

Methods: 12 optic disc topographic parameters were investigated in 36 normal eyes in 18 male monkeys. Mean (SD) and interocular differences were obtained for each parameter from three independent measurements made during a 1 week period. Correlations among the topographic parameters were analysed, too.

Results: No significant differences between right and left eyes were detected for any topographic parameters. Disc area, rim area, and height variation contour showed smaller right-left differences than other parameters. The coefficients of variation for rim area, height variation contour, rim volume, mean cup depth, maximum cup depth, mean retinal nerve fibre layer (RNFL) thickness, and RNFL cross section area were less than 10% (for rim area, less than 5%). Rim area and height variation contour showed relatively weak interrelations and neither showed a correlation with disc area.

Conclusion: For evaluating time related changes in the optic disc by HRT in monkeys, rim area and height variation contour might be useful parameters because coefficients of variation and right-left differences were lower than for other parameters and because these parameters showed weak interrelations and no correlation with disc area.

  • CA, cup area
  • C/D, cup/disc area ratio
  • CSM, cup shape measure
  • CV, cup volume
  • DA, disc area
  • HRT, Heidelberg retina tomograph
  • HVC, height variation contour
  • IOP, intraocular pressure
  • MnCD, mean cup depth
  • MnRNFLT, mean RNFL thickness
  • MxCD, maximum cup depth
  • ONH, optic nerve head
  • RA, rim area
  • RCSA, RNFL cross section area
  • RNFL, retinal nerve fibre layer
  • RV, rim volume
  • cynomolgus monkey
  • Heidelberg retina tomograph
  • optic disc
  • topographic parameter
  • CA, cup area
  • C/D, cup/disc area ratio
  • CSM, cup shape measure
  • CV, cup volume
  • DA, disc area
  • HRT, Heidelberg retina tomograph
  • HVC, height variation contour
  • IOP, intraocular pressure
  • MnCD, mean cup depth
  • MnRNFLT, mean RNFL thickness
  • MxCD, maximum cup depth
  • ONH, optic nerve head
  • RA, rim area
  • RCSA, RNFL cross section area
  • RNFL, retinal nerve fibre layer
  • RV, rim volume
  • cynomolgus monkey
  • Heidelberg retina tomograph
  • optic disc
  • topographic parameter

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