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An aim to provide an optimised keratoprosthesis, with excellent biointegration, and all other properties meeting ideal requirements, is one we share with Mehta et al.1 However, their paper includes some points that require clarification.
PHEMA (poly(2-hydroxyethyl methacrylate) is a non-toxic polymer of the toxic monomer HEMA, though cytotoxicity is still possible if non-reacted monomer has not been fully removed. The “polyhydroxyethyl methacrylate” the authors obtained for their study was not fully described, and may have been contact lens blanks, unlikely to have been processed for “implantable quality.” Whether the samples had been fully extracted was not …
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