Aims: To evaluate, with fundus perimetry, the peripapillary differential light threshold (DLT) in eyes with glaucoma and ocular hypertension (OHT), and compare it with peripapillary retinal nerve fibre layer (RNFL) thickness.
Methods: 35 glaucomatous, 29 OHT and 24 control eyes were included. Peripapillary DLT at 1° from the optic nerve head was quantified with fundus perimetry; peripapillary RNFL thickness was measured over the same area by optical coherence tomography.
Results: Mean (SD) peripapillary DLT was 19.2 (1.7), 17.6 (4.2) and 10.1 (6.9) dB in control, OHT and glaucomatous eyes, respectively (p<0.001). Mean (SD) RNFL thickness was 98.4 (35.3), 83.9 (35.1) and 55.8 (28.2) μm, respectively (p<0.001). Mean peripapillary DLT showed higher sensitivity and specificity in differentiating the three groups compared with RNFL thickness.
Conclusion: Progressive, significant reduction of peripapillary DLT was documented in OHT and glaucomatous eyes compared with controls (p<0.001). DLT reduction parallels RNFL reduction.
- AROC, area under the receiver operating characteristic curve
- DLT, differential light threshold
- IOP, intraocular pressure
- OCT, optical coherence tomography
- OHT, ocular hypertension
- ONH, optic nerve head
- RNFL, retinal nerve fibre layer
- ROC curve, receiver operating characteristic curve
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Published Online First 29 June 2006
Competing interests: None.