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Nasal natural killer (NK)/T cell lymphoma is a definitive diagnostic entity in the World Health Organization lymphoma classification.1 In many cases, NK/T cell lymphoma is invariably associated with Epstein-Barr virus (EBV). Although ocular involvement is found in less than 10% of patients with systemic lymphoma,2 because of its anatomical proximity, nasal NK/T lymphoma can sometimes complicate uveitis and orbital infiltration.3 We experienced a case of nasal NK/T lymphoma, and the cells collected from the aqueous humour originated from the lymphoma which was infected by EBV.
A 53 year old man noticed nasal obstruction and imaging demonstrated a mass lesion in the nasal cavity. The biopsy specimen from the cavity demonstrated a variety of diffuse atypical lymphoid cell infiltration. Immunohistochemically, the atypical cells showed cytoplasmic reactivity for CD56, CD3, granzyme B and perforin, but not for CD20. Many EBV encoded small RNA (EBER) positive cells were detected in the lymphoma tissues. The …
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